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Motif ID: MEF2{A,B,C,D}.p2

Z-value: 2.416

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr2_-_211168315	7.083	NM_079422	MYL1	myosin, light chain 1, alkali; skeletal, fast
chrX_-_21776158	7.071	NM_014332	SMPX	small muscle protein, X-linked
chr10_-_75415748	5.919	NM_001114133	SYNPO2L	synaptopodin 2-like
chr1_-_116311161	5.855		CASQ2	calsequestrin 2 (cardiac muscle)
chr1_-_116311330	5.839		CASQ2	calsequestrin 2 (cardiac muscle)
chr1_-_116311398	5.692	NM_001232	CASQ2	calsequestrin 2 (cardiac muscle)
chr2_-_190927321	5.275	NM_005259	MSTN	myostatin
chr2_+_170366211	4.694	NM_006063	KBTBD10	kelch repeat and BTB (POZ) domain containing 10
chr10_-_75410778	4.676	NM_024875	SYNPO2L	synaptopodin 2-like
chr12_+_81101407	4.561	NM_002469	MYF6	myogenic factor 6 (herculin)
chr1_-_201390845	4.421	NM_003281	TNNI1	troponin I type 1 (skeletal, slow)
chr1_-_201346783	4.063		TNNT2	troponin T type 2 (cardiac)
chr1_-_201346804	4.001	NM_000364 NM_001001430 NM_001001431 NM_001001432	TNNT2	troponin T type 2 (cardiac)
chr5_+_53751430	3.745	NM_006308	HSPB3	heat shock 27kDa protein 3
chr1_-_153518265	3.616	NM_002961 NM_019554	S100A4	S100 calcium binding protein A4
chr17_-_10325266	3.277	NM_002472	MYH8	myosin, heavy chain 8, skeletal muscle, perinatal
chr9_+_139871954	3.229	NM_000954	PTGDS	prostaglandin D2 synthase 21kDa (brain)
chr5_+_155753755	3.186	NM_000337 NM_001128209 NM_172244	SGCD	sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr20_+_9288446	3.155	NM_000933	PLCB4	phospholipase C, beta 4
chr2_-_211179765	3.055	NM_079420	MYL1	myosin, light chain 1, alkali; skeletal, fast
chr6_-_169653922	2.980		THBS2	thrombospondin 2
chr12_-_111358353	2.876	NM_000432	MYL2	myosin, light chain 2, regulatory, cardiac, slow
chr12_+_119616594	2.873	NM_014365	HSPB8	heat shock 22kDa protein 8
chr9_+_139872014	2.872		PTGDS	prostaglandin D2 synthase 21kDa (brain)
chr5_-_111091947	2.830	NM_001142483	C5orf13	chromosome 5 open reading frame 13
chr6_-_169654047	2.827	NM_003247	THBS2	thrombospondin 2
chr5_-_83016850	2.718	NM_001884	HAPLN1	hyaluronan and proteoglycan link protein 1
chr3_+_138067678	2.632	NM_001252092	MRAS	muscle RAS oncogene homolog
chr14_-_103989195	2.462	NM_001823	CKB	creatine kinase, brain
chr3_+_8775485	2.443	NM_001234 NM_033337	CAV3	caveolin 3
chr5_-_42811959	2.407	NM_001085486 NM_001093726 NM_005410	SEPP1	selenoprotein P, plasma, 1
chr3_+_35721115	2.349	NM_001025068 NM_001025069	ARPP21	cAMP-regulated phosphoprotein, 21kDa
chr21_+_30517897	2.336		C21orf7	chromosome 21 open reading frame 7
chr14_-_103988829	2.272		CKB	creatine kinase, brain
chr17_+_45286713	2.170	NM_002476	MYL4	myosin, light chain 4, alkali; atrial, embryonic
chrX_+_70521627	2.153	NM_012278	ITGB1BP2	integrin beta 1 binding protein (melusin) 2
chr4_+_169418167	2.153	NM_001166108 NM_016081	PALLD	palladin, cytoskeletal associated protein
chr10_+_91152321	2.136	NM_001548	IFIT1	interferon-induced protein with tetratricopeptide repeats 1
chrX_+_153046422	1.938	NM_001170760 NM_001170761 NM_014370	SRPK3	SRSF protein kinase 3
chr14_-_103989112	1.929		CKB	creatine kinase, brain
chr2_+_233498206	1.852	NM_025202	EFHD1	EF-hand domain family, member D1
chr4_+_41362750	1.791	NM_001112717 NM_001112718 NM_014988	LIMCH1	LIM and calponin homology domains 1
chr17_+_1665306	1.751		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_114343052	1.727	NM_001164347	ZBTB20	zinc finger and BTB domain containing 20
chr17_-_10421858	1.710	NM_005963	MYH1	myosin, heavy chain 1, skeletal muscle, adult
chr1_-_57045129	1.636		PPAP2B	phosphatidic acid phosphatase type 2B
chr2_-_163099877	1.617	NM_004460	FAP	fibroblast activation protein, alpha
chr17_+_1665342	1.573		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_+_101185195	1.557	NM_001078 NM_001199834 NM_080682	VCAM1	vascular cell adhesion molecule 1
chr1_+_145524989	1.552	NM_003637	ITGA10	integrin, alpha 10
chr4_-_186697065	1.549	NM_001145673	SORBS2	sorbin and SH3 domain containing 2
chr13_-_36429798	1.548	NM_001195415 NM_001195416 NM_001195430	DCLK1	doublecortin-like kinase 1
chr5_-_150521200	1.530	NM_001193544	ANXA6	annexin A6
chr17_+_1665233	1.517	NM_002615	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665281	1.517		SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_+_8543539	1.465		LMCD1	LIM and cysteine-rich domains 1
chr4_+_120056938	1.447	NM_016599	MYOZ2	myozenin 2
chr17_+_45286427	1.418	NM_001002841	MYL4	myosin, light chain 4, alkali; atrial, embryonic
chr21_+_27011588	1.371	NM_021219	JAM2	junctional adhesion molecule 2
chr12_-_16759939	1.360	NM_001243613	LMO3	LIM domain only 3 (rhombotin-like 2)
chr3_+_8543508	1.354	NM_014583	LMCD1	LIM and cysteine-rich domains 1
chr13_+_76334796	1.351	NM_015842	LMO7	LIM domain 7
chr2_-_190044330	1.344	NM_000393	COL5A2	collagen, type V, alpha 2
chr11_+_131240370	1.334	NM_001048209	NTM	neurotrimin
chr2_-_175712276	1.280	NM_001206602	CHN1	chimerin (chimaerin) 1
chr4_-_186877413	1.264		SORBS2	sorbin and SH3 domain containing 2
chr11_+_1860232	1.250	NM_003282	TNNI2	troponin I type 2 (skeletal, fast)
chr1_+_78470593	1.246	NM_007034	DNAJB4	DnaJ (Hsp40) homolog, subfamily B, member 4
chr3_+_138067444	1.226	NM_001085049 NM_001252093	MRAS	muscle RAS oncogene homolog
chr1_-_57045235	1.214	NM_003713	PPAP2B	phosphatidic acid phosphatase type 2B
chr10_-_62703822	1.207	NM_001242359 NM_014836	RHOBTB1	Rho-related BTB domain containing 1
chr7_-_143582363	1.205	NM_001206941	FAM115A	family with sequence similarity 115, member A
chr10_+_88428167	1.193	NM_001171610	LDB3	LIM domain binding 3
chr17_-_3599359	1.188		P2RX5	purinergic receptor P2X, ligand-gated ion channel, 5
chr6_-_24877453	1.164	NM_015864	FAM65B	family with sequence similarity 65, member B
chr19_-_20607761	1.162		ZNF826P	zinc finger protein 826, pseudogene
chr4_-_143767603	1.158	NM_001101669 NM_003866	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa
chr10_+_88428263	1.126	NM_001080116 NM_001080114 NM_001080115 NM_001171611 NM_007078	LDB3	LIM domain binding 3
chr13_-_34250899	1.120	NM_001243476	STARD13	StAR-related lipid transfer (START) domain containing 13
chr19_-_45822841	1.076		CKM	creatine kinase, muscle
chr9_+_124048396	1.061		GSN	gelsolin
chr10_+_63808968	1.027	NM_001244638	ARID5B	AT rich interactive domain 5B (MRF1-like)
chr15_+_100173182	0.987	NM_001130928	MEF2A	myocyte enhancer factor 2A
chr12_-_16758312	0.980	NM_001243611	LMO3	LIM domain only 3 (rhombotin-like 2)
chr11_+_1860718	0.979	NM_001145829	TNNI2	troponin I type 2 (skeletal, fast)
chr1_-_204329043	0.967	NM_014935	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr1_+_160085519	0.935	NM_000702	ATP1A2	ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr8_+_70378858	0.934	NM_001128204 NM_015170	SULF1	sulfatase 1
chr9_+_97521930	0.914	NM_001193329	C9orf3	chromosome 9 open reading frame 3
chr1_-_57044980	0.909		PPAP2B	phosphatidic acid phosphatase type 2B
chr8_+_1993157	0.906	NM_003970	MYOM2	myomesin (M-protein) 2, 165kDa
chr2_+_220283098	0.889	NM_001927	DES	desmin
chr12_-_16760935	0.887	NM_001001395 NM_001243609	LMO3	LIM domain only 3 (rhombotin-like 2)
chrX_-_11284094	0.854	NM_013423	ARHGAP6	Rho GTPase activating protein 6
chr19_+_3933100	0.852	NM_170678	ITGB1BP3	integrin beta 1 binding protein 3
chr10_-_74283693	0.822	NM_001195519	MICU1	mitochondrial calcium uptake 1
chr16_-_31439650	0.820	NM_005205	COX6A2	cytochrome c oxidase subunit VIa polypeptide 2
chr1_-_31845818	0.795	NM_004102	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr1_-_202936333	0.795	NM_016243	CYB5R1	cytochrome b5 reductase 1
chr22_-_30642683	0.762	NM_002309	LIF	leukemia inhibitory factor (cholinergic differentiation factor)
chr11_+_60260250	0.761	NM_001164470 NM_017716	MS4A12	membrane-spanning 4-domains, subfamily A, member 12
chr10_-_92681025	0.759	NM_014391	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)
chr3_-_99833348	0.753	NM_001042459 NM_182909	FILIP1L	filamin A interacting protein 1-like
chr12_-_6665220	0.745	NM_001039670 NM_001193457 NM_080730	IFFO1	intermediate filament family orphan 1
chrX_-_6146655	0.735	NM_181332	NLGN4X	neuroligin 4, X-linked
chr17_-_76975932	0.734	NM_005567	LGALS3BP	lectin, galactoside-binding, soluble, 3 binding protein
chr17_-_29648631	0.731	NM_001003927 NM_014210	EVI2A	ecotropic viral integration site 2A
chr4_-_186733372	0.726	NM_003603 NM_001145670	SORBS2	sorbin and SH3 domain containing 2
chr4_+_169552752	0.725	NM_001166109	PALLD	palladin, cytoskeletal associated protein
chr1_-_230849863	0.722		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr3_+_179370779	0.712	NM_003940	USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)
chr11_+_69467210	0.710		CCND1	cyclin D1
chr15_+_68908878	0.708	NM_001190456	CORO2B	coronin, actin binding protein, 2B
chr1_+_183114214	0.693		LAMC1	laminin, gamma 1 (formerly LAMB2)
chr8_-_119964059	0.693	NM_002546	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b
chr9_+_4679557	0.693	NM_017913	CDC37L1	cell division cycle 37 homolog (S. cerevisiae)-like 1
chr1_-_86043932	0.692	NM_001134445	DDAH1	dimethylarginine dimethylaminohydrolase 1
chr1_+_210501595	0.689	NM_001122834 NM_001170564	HHAT	hedgehog acyltransferase
chr13_-_52980628	0.669	NM_018676 NM_199263	THSD1	thrombospondin, type I, domain containing 1
chr3_-_145878775	0.661		PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr17_-_48945338	0.638	NM_001243877	TOB1	transducer of ERBB2, 1
chr12_+_57157091	0.624	NM_003725	HSD17B6	hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
chr1_+_156211950	0.613	NM_199173	BGLAP	bone gamma-carboxyglutamate (gla) protein
chr12_-_16759531	0.612	NM_018640	LMO3	LIM domain only 3 (rhombotin-like 2)
chr2_-_152590983	0.601	NM_001164507 NM_001164508 NM_004543	NEB	nebulin
chr12_-_16759430	0.595		LMO3	LIM domain only 3 (rhombotin-like 2)
chr1_+_151032866	0.587		MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr3_+_138066489	0.584	NM_001252091 NM_012219	MRAS	muscle RAS oncogene homolog
chr14_-_102771469	0.580	NM_014226	MOK	MOK protein kinase
chr12_+_81110689	0.571	NM_005593	MYF5	myogenic factor 5
chr1_+_151032880	0.570		MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr15_+_100106132	0.568	NM_001130926 NM_001130927 NM_001171894 NM_005587	MEF2A	myocyte enhancer factor 2A
chr15_+_100106214	0.565		MEF2A	myocyte enhancer factor 2A
chr1_+_151032683	0.552		MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr6_-_116447225	0.550	NM_000493	COL10A1	collagen, type X, alpha 1
chr15_+_100106179	0.549		MEF2A	myocyte enhancer factor 2A
chr2_+_109204777	0.547		LIMS1	LIM and senescent cell antigen-like domains 1
chr19_+_22469251	0.538	NM_001242680	ZNF729	zinc finger protein 729
chr17_+_80186886	0.537	NM_004207	SLC16A3	solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
chr10_-_95241943	0.527	NM_013451 NM_133337	MYOF	myoferlin
chr7_-_64023331	0.527		ZNF680	zinc finger protein 680
chr18_-_3219986	0.519	NM_003803 NM_019856	MYOM1	myomesin 1, 185kDa
chr9_+_100263818	0.508	NM_003275	TMOD1	tropomodulin 1
chr2_+_172378756	0.508		CYBRD1	cytochrome b reductase 1
chr9_-_130639939	0.495	NM_000476	AK1	adenylate kinase 1
chr16_-_28550324	0.494	NM_001042483 NM_012385	NUPR1	nuclear protein, transcriptional regulator, 1
chr12_-_9268440	0.491		A2M	alpha-2-macroglobulin
chr4_-_156874993	0.488	NM_001334	CTSO	cathepsin O
chr6_-_131321868	0.486	NM_001252660	EPB41L2	erythrocyte membrane protein band 4.1-like 2
chr2_+_201473942	0.480		AOX1	aldehyde oxidase 1
chr2_-_217560247	0.477	NM_000599	IGFBP5	insulin-like growth factor binding protein 5
chr7_+_155250705	0.473	NM_001427	EN2	engrailed homeobox 2
chr8_-_49833823	0.473	NM_003068	SNAI2	snail homolog 2 (Drosophila)
chr13_-_38172862	0.472	NM_001135934 NM_001135935 NM_001135936 NM_006475	POSTN	periostin, osteoblast specific factor
chr1_+_244216506	0.471	NM_006352	ZNF238	zinc finger protein 238
chr7_-_64023454	0.468	NM_001130022 NM_178558	ZNF680	zinc finger protein 680
chr2_-_106055229	0.464	NM_201557	FHL2	four and a half LIM domains 2
chr6_-_116575170	0.464	NM_021648	TSPYL4	TSPY-like 4
chr6_+_25962978	0.449	NM_006355	TRIM38	tripartite motif containing 38
chr4_+_129730772	0.449	NM_024900 NM_199320	PHF17	PHD finger protein 17
chr6_-_46293628	0.448	NM_005822	RCAN2	regulator of calcineurin 2
chr1_+_25757381	0.447	NM_018202	TMEM57	transmembrane protein 57
chr12_-_16759733	0.447	NM_001243610	LMO3	LIM domain only 3 (rhombotin-like 2)
chr2_-_55199894	0.444
chr10_+_5488521	0.444	NM_005863	NET1	neuroepithelial cell transforming 1
chr19_-_22966972	0.443	NM_001080409	ZNF99	zinc finger protein 99
chr5_-_142065586	0.442	NM_000800	FGF1	fibroblast growth factor 1 (acidic)
chrY_+_22737610	0.436	NM_004681	EIF1AY	eukaryotic translation initiation factor 1A, Y-linked
chr12_+_15699277	0.435	NM_030668 NM_030669 NM_030670 NM_030671	PTPRO	protein tyrosine phosphatase, receptor type, O
chr17_-_1389013	0.434	NM_001080950	MYO1C	myosin IC
chr6_-_26124130	0.430	NM_003526	HIST1H2BG HIST1H2BC	histone cluster 1, H2bg histone cluster 1, H2bc
chr5_-_114515733	0.428	NM_001017397 NM_001017398 NM_018700	TRIM36	tripartite motif containing 36
chr2_+_85766286	0.426		MAT2A	methionine adenosyltransferase II, alpha
chr2_-_10588451	0.426	NM_002539	ODC1	ornithine decarboxylase 1
chr15_+_80390757	0.419	NM_001242919	ZFAND6	zinc finger, AN1-type domain 6
chr7_+_45933096	0.406
chr15_+_80364902	0.405	NM_001242915 NM_001242916	ZFAND6	zinc finger, AN1-type domain 6
chr1_+_59775749	0.405	NM_001244714	FGGY	FGGY carbohydrate kinase domain containing
chr1_-_230849847	0.399		AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr1_-_230850335	0.394	NM_000029	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr4_+_70861647	0.392	NM_001009181 NM_003154	STATH	statherin
chr2_+_161993465	0.390	NM_004180 NM_133484	TANK	TRAF family member-associated NFKB activator
chr20_+_9049660	0.387	NM_001172646	PLCB4	phospholipase C, beta 4
chr19_+_23299776	0.386		ZNF730	zinc finger protein 730
chr4_+_78079302	0.384		CCNG2	cyclin G2
chr4_-_70361578	0.383	NM_021139	UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4
chr2_+_233470766	0.381	NM_001243252	EFHD1	EF-hand domain family, member D1
chr3_+_135741576	0.380	NM_181897	PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha
chr19_+_7504573	0.379	NM_001130955	ARHGEF18	Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr2_+_38893051	0.371	NM_138801	GALM	galactose mutarotase (aldose 1-epimerase)
chrX_-_128657381	0.362		SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr1_+_151032150	0.360	NM_006818	MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr9_+_103947316	0.356	NM_017753	LPPR1	lipid phosphate phosphatase-related protein type 1
chr17_-_3599487	0.354	NM_001204519 NM_001204520 NM_002561 NM_175080	P2RX5-TAX1BP3 P2RX5	P2RX5-TAX1BP3 readthrough purinergic receptor P2X, ligand-gated ion channel, 5
chr7_+_64838791	0.352		ZNF92	zinc finger protein 92
chr2_-_10588273	0.352		ODC1	ornithine decarboxylase 1
chr14_-_69262959	0.351	NM_001244701	ZFP36L1	zinc finger protein 36, C3H type-like 1
chr14_+_71996041	0.350	NM_015556	SIPA1L1	signal-induced proliferation-associated 1 like 1
chrX_-_128657453	0.348	NM_003069 NM_139035	SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr3_-_145878936	0.346		PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2

Gene overrepresentation in process category:

Enrichment	P-value	GO Accession	GO Term
16.99	1.71e-11	GO:0007517	muscle organ development
11.99	2.08e-09	GO:0061061	muscle structure development
37.40	1.87e-07	GO:0030049	muscle filament sliding
37.40	1.87e-07	GO:0033275	actin-myosin filament sliding
12.96	2.15e-07	GO:0003012	muscle system process
36.42	2.28e-07	GO:0070252	actin-mediated cell contraction
12.85	1.51e-06	GO:0006936	muscle contraction
27.14	1.99e-06	GO:0030048	actin filament-based movement
32.95	7.77e-06	GO:0006941	striated muscle contraction
8.15	1.14e-04	GO:0030029	actin filament-based process
2.80	2.25e-03	GO:0048513	organ development
2.32	3.90e-03	GO:0048731	system development
16.76	3.94e-03	GO:0009408	response to heat
59.30	5.05e-03	GO:0014743	regulation of muscle hypertrophy
2.17	8.29e-03	GO:0048856	anatomical structure development
14.13	9.14e-03	GO:0090257	regulation of muscle system process
22.60	9.61e-03	GO:0048644	muscle organ morphogenesis
10.76	3.41e-02	GO:0009266	response to temperature stimulus
31.22	3.95e-02	GO:0003015	heart process
31.22	3.95e-02	GO:0060047	heart contraction

Gene overrepresentation in compartment category:

Enrichment	P-value	GO Accession	GO Term
29.37	1.02e-16	GO:0044449	contractile fiber part
28.52	1.62e-16	GO:0030016	myofibril
26.72	4.51e-16	GO:0043292	contractile fiber
29.89	2.00e-14	GO:0030017	sarcomere
9.94	3.35e-08	GO:0015629	actin cytoskeleton
43.93	1.47e-04	GO:0005859	muscle myosin complex
39.54	2.31e-04	GO:0016460	myosin II complex
84.71	3.66e-04	GO:0005861	troponin complex
18.31	6.24e-04	GO:0016459	myosin complex
3.13	6.91e-04	GO:0005856	cytoskeleton
24.72	1.64e-03	GO:0030018	Z disc
45.62	2.93e-03	GO:0005865	striated muscle thin filament
19.30	4.47e-03	GO:0031674	I band

Gene overrepresentation in function category:

Enrichment	P-value	GO Accession	GO Term
8.04	6.54e-06	GO:0003779	actin binding
5.37	1.24e-04	GO:0008092	cytoskeletal protein binding
24.12	1.31e-04	GO:0008307	structural constituent of muscle
4.09	4.55e-03	GO:0005509	calcium ion binding
98.83	1.09e-02	GO:0004111	creatine kinase activity
9.34	1.38e-02	GO:0003774	motor activity
79.07	1.82e-02	GO:0032036	myosin heavy chain binding